Endometrial receptivity and PCOS; endometrial gene expression specificities — literature review

Objectives: The purpose of this review is to provide an overview existing studies on the specificities gene expression in endometrium PCOS and possible molecular mechanisms linking those with reproductive obstetric consequences PCOS. Mechanism: Polycystic ovary syndrome (PCOS) a complex disorder combining features reproductive, metabolic, psychological disturbances. effect inflammatory, endocrine abnormalities ovulatory function oocyte quality has been seen as main issue women. However, even after restoration ovulation, group exhibits lower than expected outcomes. Functionally relevant sequence alterations genes involved regulating endometrial receptivity could also be property independent extra-endometrial influences. Findings: Hyperandrogenism, dysfunction, insulin resistance are associated expressions leading suboptimal Endometrial steroid receptor malfunction seems contibuting factor intrinsic Conclusion: epigenetic or epigenomics altering level should not ruled out. Future focus investigating each phenotype developing individual treatment strategies meet specific needs every patient.